Waldenström macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a rare and indolent B-cell lymphoma that occurs in <2% of non-Hodgkin’s lymphoma (NHL) patients. It is characterized by large amounts of immunoglobulin M (IgM) in the blood, which can lead to hyperviscosity syndrome. WM is mainly found in the bone marrow; however, the spleen and lymph nodes may also be involved. 

WM is sometimes asymptomatic, but when symptoms do occur, they may be similar to other NHL subtypes. Common symptoms of the disease include neuropathy, appetite loss, weight loss, sweats, fever, and weakness. Other symptoms of WM are abdominal swelling, vision problems, enlarged lymph nodes, digestive and nervous system symptoms, abnormal bleeding, sensitivity to cold, and infections. Due to the large amount of abnormal IgM antibody made by cancer cells, patients with WM can also develop amyloidosis, hyperviscosity syndrome, or cryoglobulins. 

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